Long-term <i>trans</i>-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid

نویسندگان

چکیده

The hepatic bile acid transporter NTCP is a high-affinity receptor for hepatitis B and D viruses. This study shows that TLC rapidly accumulates in NTCP-expressing hepatoma cells mediates long-lasting trans-inhibition of NTCP’s function via an intracellularly accessible domain, without substantially affecting its membrane expression. domain promising novel target site pharmacological long-acting HBV/HDV entry inhibitors.

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ژورنال

عنوان ژورنال: American Journal of Physiology-gastrointestinal and Liver Physiology

سال: 2021

ISSN: ['0193-1857', '1522-1547']

DOI: https://doi.org/10.1152/ajpgi.00263.2020